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KMID : 0387420100210010059
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Korean Society of Oriental Neuropsychiatry
2010 Volume.21 No. 1 p.59 ~ p.69
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A Study on the Effects of the Electro-Acupuncture(EA) Stimulation after Global Ischemia(GI) on Changes in Bax and Caspase-3 Expression among Forebrain Apoptosis
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Choi Jung-Hyun
Min Kyung-Ok
Kim Dong-Il
Lee Sang-Bin
Ahn Ho-Jung
Kim Ji-Sung
Choi Wan-Suk
Kim Bo-Kyoung
Song Chi-Won
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Abstract
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Objectives: The study aims to look into how the application of EA(Electro-acupuncture) in the initial step of ischemic brain injury affects the changes in Bax and Caspase-3 expression among forebrain apoptosis.
Methods: It caused GI by using common carotid artery occlusion and conducted the test by dividing into the no applied EA group after 6 hours and 12 hours, the LI 4 EA group that applied EA to LI4, and GV 20 EA group that was applied to GV 20. After that, the following results were obtained by comparing Bax and Caspase-3 expression, which were apoptosis-related factors, with its application time through immunohistochemical staining after extracting brain of each group.
Results: According to each group’s Bax expression by the application time, the order of expression increase after 6 hours is shown to be the no applied EA group, LI 4 group, and GV 20 group. The stimulation after 12 hours was most lowly expressed in the GV 20 group, and the no applied EA group and LI 4 group showed similar level.
Conclusions: EA stimulation in the initial step after ischemia seems to affect positively Bax and Caspase-3 expression that are index of forebrain apoptosis.
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KEYWORD
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Global ischemia, Electrical acupuncture, Bax, Caspase-3
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